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  • Title: The effects of burimamide and metiamide on basal gastric function in the cat.
    Author: Harris DW, Smy JR, Reed JD, Venables CW.
    Journal: Br J Pharmacol; 1975 Feb; 53(2):293-7. PubMed ID: 238700.
    Abstract:
    1 Burimamide injected intravenously in the anaesthetized or conscious cat produced significant increases in gastric acid secretion: in the anaesthetized cat it produced increased gastric mucosal blood flow. 2 Metiamide, in doses which inhibited pentagastrin-stimulated acid secretion, produced no increase in gastric acid secretion in conscious animals, or gastric acid secretion or gastric mucosal blood flow in the anaesthetized cat. 3 Metiamide did not influence the amount of acid which diffused out of the stomach when instilled at pH values between 1.5 and 6.0. 4 The possible mode of action of burimamide in increasing basal gastric secretion is discussed.
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