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  • Title: [The relationship between the chemical structure and anti-arrhythmia action of a number of omega-aminoacyl-3-carbalcoxyaminodibenzazepines].
    Author: Gritsenko AN, Lyskovtsev VV, Senova ZP, Skoldinov AP, Stark A, Wunderlich G, Poppe H, Barch R.
    Journal: Farmakol Toksikol; 1990; 53(3):30-2. PubMed ID: 2387375.
    Abstract:
    The antiarrhythmic activity of 20 derivatives of dibenzazepine (the effects on the maximal effective rabbit heart auricle contraction rate, aconitine-induced arrhythmia in rats under or without anesthesia) was studied. It was shown that the most active compounds are those with carbethoxyamine group in position 3 in combination with dimethylamino- or diethylamino-acetyl groups in position 5 of dibenzazepine ring. 5-dimethyl-aminoacetyl-10,11-dihydro-5H-dibenz b, f azepine (GS-015, bonnecor) was selected for the further detailed investigation.
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