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  • Title: Assessment of L-arginine asymmetric 1 dimethyl (ADMA) in early-onset and late-onset (severe) preeclampsia.
    Author: Alpoim PN, Godoi LC, Freitas LG, Gomes KB, Dusse LM.
    Journal: Nitric Oxide; 2013 Sep 01; 33():81-2. PubMed ID: 23876347.
    Abstract:
    Preeclampsia (PE) is characterized by hypertension and proteinuria. It has been classified in early or late according to gestational age at the onset of disease. Endothelial dysfunction plays a crucial part in its pathogenesis. NO is a potent vasodilator and ADMA is its endogenous inhibitor. We have assessed maternal ADMA levels. ADMA were increased in early [0.66 μmol/L] versus late sPE [0.47 μmol/L] (P=0.001) and versus normotensive pregnant [0.48 μmol/L] (P=0.001). Our findings suggest that high ADMA levels in early sPE could compromise NO synthesis contributing to endothelial dysfunction, leading to impaired placentation and the onset of this disease.
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