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  • Title: Modifications of the cerebral electric activity induced by the intracerebroventricular injection of acetyl-L-carnitine in cats.
    Author: Mancia M, Imeri L, Giglio R.
    Journal: Int J Clin Pharmacol Res; 1990; 10(1-2):115-21. PubMed ID: 2387658.
    Abstract:
    The intracerebroventricular (i.c.v.) injection of acetyl-L-carnitine in the freely moving cat, during a spontaneous synchronous phase of sleep, induced the animal's arousal and a delay of the subsequent appearance of desynchronized sleep. The entity of such effects was dose dependent. The i.c.v. but not the intravenous injection of the drug proved capable of inducing a desynchronization of the characteristically synchronous electroencephalogram of an animal with a brainstem section at intercollicular midbrain level (cerveau isolé preparation), thus suggesting that the action of acetyl-L-carnitine could be exerted at a diencephalic level. Acetyl-L-carnitine could therefore modulate the sleep-wake cycle, thus facilitating the desynchronizing systems of cerebral electric activity.
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