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  • Title: Altered vitamin B6 homeostasis during aminophylline infusion in the beagle dog.
    Author: Delport R, Ubbink JB, Bosman H, Bissbort S, Vermaak WJ.
    Journal: Int J Vitam Nutr Res; 1990; 60(1):35-40. PubMed ID: 2387668.
    Abstract:
    The effect of intravenous infusion of aminophylline, a strong inhibitor of pyridoxal kinase, on intra- and extracellular vitamin B6 homeostasis was investigated in four beagle dogs. Plasma and erythrocyte pyridoxal levels increased by 118% and 117% respectively after 3 hours of aminophylline infusion, (4 mg/kg body weight/hour), however, infusion of beta-hydroxyethyltheophylline, which does not inhibit pyridoxal kinase, had no effect on either intra- or extracellular vitamin B6 aldehyde derivative levels. It is suggested that theophylline induced pyridoxal kinase inhibition resulted in a disturbed equilibrium between pyridoxal and pyridoxal 5'-phosphate.
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