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  • Title: Synthesis of functionalized isoquinolin-1(2H)-ones by copper-catalyzed α-arylation of ketones with 2-halobenzamides.
    Author: Shi Y, Zhu X, Mao H, Hu H, Zhu C, Cheng Y.
    Journal: Chemistry; 2013 Aug 26; 19(35):11553-7. PubMed ID: 23881785.
    Abstract:
    Copper is key: A concise route to isoquinolin-1(2H)-ones from simple and readily available starting materials is provided by an efficient copper-catalyzed annulation of ketones with 2-halobenzamides. The method is applicable to a wide range of ketones containing different functional groups furnishing the products in moderate to excellent yields.
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