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Title: Synthesis and preliminary biological evaluations of 5'-substituted derivatives of uridine as glycosyltransferase inhibitors. Author: Paszkowska J, Kral K, Bieg T, Nawrot U, Szeja W, Wandzik I. Journal: Molecules; 2013 Jul 08; 18(7):8018-27. PubMed ID: 23884133. Abstract: New derivatives of uridine which contain a b-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1-4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.[Abstract] [Full Text] [Related] [New Search]