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  • Title: Possible gadolinium ions leaching and MR sensitivity over-estimation in mesoporous silica-coated upconversion nanocrystals.
    Author: Zhang S, Jiang Z, Liu X, Zhou L, Peng W.
    Journal: Nanoscale; 2013 Sep 07; 5(17):8146-55. PubMed ID: 23884249.
    Abstract:
    Mesoporous silica (m-SiO2) coated gadolinium (Gd) ions-doped upconversion nanoparticles (UCNPs) are regarded as one of most attractive nano-platforms which hold great potential in future cancer theranostics. The current general synthetic strategy for such promising structures includes the extraction of surfactant molecules in the final step. Here, in this article, we focus our interest on probing the potential influence of hydrochloric acid extraction on lanthanide ions leakage, MR sensitivity over-estimation and the optical intensity weakening of m-SiO2 coated Gd-doped UCNPs. Control experiments provide evidence of inner core damage, Gd(3+) ion release and residual Gd(3+) ions "trapped" within the core@shell structures. Our investigation shows that: (1) the small Gd-doped UCNPs could be fragile and sensitive to the hydrochloric acid-extraction and thermal treatment processes; and (2) the presence of "trapped" Gd(3+) ions not only provokes the concerns of potential cytotoxicity but also interfere with the contrast imaging tests of Gd-doped UCNPs, providing possible erroneous information on the determination of the longitudinal relaxivities of given probes.
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