These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of carvedilol on cardiac dysfunction 4 days after myocardial infarction in rats: role of toll-like receptor 4 and β-arrestin 2.
    Author: Liu CC, Huang Y, Zhang JH, Xu Y, Wu CH.
    Journal: Eur Rev Med Pharmacol Sci; 2013; 17(15):2103-10. PubMed ID: 23884833.
    Abstract:
    OBJECTIVES: To assess the beneficial effect of carvedilol treatment on infarct myocardium and the relation to the expression of nuclear factor-kappa B (NF-κB), Toll-like receptor 4 (TLR4), and β-arrestin 2. MATERIALS AND METHODS: Rat myocardial infarction (MI) model was produced by ligating the left anterior descending coronary artery. Forty-eight rats were randomized to the following groups before surgery: sham-operated group (n=8), MI group (n=10), and three carvedilol-treatment groups (n=30, 2 mg/kg, 10 mg/kg and 30 mg/kg). RESULTS: Four days after MI, carvedilol treatment could ameliorate left ventricular dysfunction by inhibiting the MI-induced increase of left ventricular end diastolic pressure and the decrease of left ventricle end systolic pressure and the changes to their maximum rates (+dp/dtmax and -dp/dtmax). Histological examination showed that carvedilol attenuated myocardium necrosis and inflammatory cell infiltration. In parallel, the treatment also suppressed the expression of NF-κB and TLR4 induced by MI, but increased the expression of β-arrestin 2. CONCLUSIONS: These results indicate that short term administration of carvedilol could improve early cardiac dysfunction in a rat model of MI. This beneficial effect may be attributed to inhibit the expression of NF-κB and TLR4, but induce the expression of β-arrestin 2 in the infarct region of the myocardium, which would suppress inflammation.
    [Abstract] [Full Text] [Related] [New Search]