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  • Title: Reduction of adverse acute cardiovascular actions of 6-hydroxydopamine in dogs by adrenergic receptor blockade.
    Author: Burks TF, Grubb MN, Peterson RG.
    Journal: Eur J Pharmacol; 1975; 32(02):387-92. PubMed ID: 238861.
    Abstract:
    Injection of dogs with 50 mg/kg of 6-hydroxydopamine (6-OHDA) caused large increases in blood pressure and heart rate, followed after 1 or 2 hr by severe hypotension. Prior administration of the adrenergic receptor blocking agents phentolamine and propranolol attenuated both the hyper- and hypotensive phases of 6-OHDA. Phentolamine and propranolol did not prevent depletionof norepinephrine or development of the characteristic morphological changes induced in adrenergic fibers by 6-OHDA.
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