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  • Title: [The efficacy of antioxidant therapy in patients with tuberculosis of the lungs and the correction of lipid peroxidation processes].
    Author: Safarian MD, Karagezian KG, Karapetian ET, Avanesian NA.
    Journal: Probl Tuberk; 1990; (5):40-4. PubMed ID: 2388892.
    Abstract:
    The article deals with the efficacy of the antioxidative therapy in tuberculosis. Besides chemotherapeutic drugs, the administration of alpha-tocopherol, vitamin C and sodium nucleinate brings about higher rates of smear-negative cases and shorter period of cavity closure. In case of tuberculosis, lipid peroxidation (LPO) stimulation accompanied by a sharp drop of superoxide dismutase (SOD) enzyme activity is observed. This process is considered to be a manifestation of the decompensation taking place in the antiradical cell defense systems. In the course of treatment, the LPO level seems to decrease, while SOD activity and SOD/LPO ratio tend to rise. The comparison of the results obtained in every group indicated that a combined administration of alpha-tocopherol, vitamin C and sodium nucleinate proved to be the most effective.
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