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  • Title: [Chlorozyl, a new Soviet M-cholinolytic agent, and its effectiveness in duodenal ulcer].
    Author: Tsimmerman IaS, Syman LN, Golovanova ES.
    Journal: Sov Med; 1990; (5):39-43. PubMed ID: 2389199.
    Abstract:
    The efficacy of a new peripheral M-cholinolytic, chlorozyl, was studied in two representative groups of duodenal ulcer patients and compared with that of atropine sulfate. The effects of single doses of chlorozyl and atropine on gastric acid production and motor function were under study, as was the effect of a course of treatment lasting 24-26 days on clinical symptoms, impaired gastric functions, healing of the ulcer defect, and remote results (in 1-3 years). The findings evidence that chlorozyl drastically inhibited gastric acid production and normalized motor function after a single administration and a course of treatment (in combination with antacids), rapidly alleviated painful and dyspeptic syndromes and provided ulcer cicatrization in 82 percent of patients, reduced the incidence of recurrences twofold within the first year after a course of treatment. Chlorozyl is much superior to atropine in respect of all the parameters listed; side effects are more rare, this being due to the fact that it poorly penetrates the hematoencephalic barrier and its central effect is weaker.
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