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  • Title: [The trypsin cleavage of hemagglutinin enhances the infectivity of the influenza virus in mice].
    Author: Zhirnov OP.
    Journal: Vopr Virusol; 1990; 35(2):117-9. PubMed ID: 2389564.
    Abstract:
    Mouse-pathogenic influenza A/Aichi 2/68 (H3N2) grown in cell culture and having uncleaved hemagglutinin HA after treatment with trypsin underwent proteolytic shearing of HA (m.w. 75 kD) into two fragments: NAL (60 kD) and HA2 (15 kD); its lethal effect on mice inoculated intranasally increased more than 200-fold. The virus treated with chemotrypsin underwent similar shearing of HA into HAL and HA2; however, its lethal effect on mice was weak, analogous to that of intact virus with uncleaved HA.
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