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  • Title: Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus.
    Author: Kim JY, Lee H, Oh KS, Kweon S, Jeon OC, Byun Y, Kim K, Kwon IC, Kim SY, Yuk SH.
    Journal: Biomaterials; 2013 Nov; 34(33):8444-9. PubMed ID: 23895999.
    Abstract:
    A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures.
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