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  • Title: Photo-ionization and photo-excitation of curcumin investigated by laser flash photolysis.
    Author: Qian T, Kun L, Gao B, Zhu R, Wu X, Wang S.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2013 Dec; 116():6-12. PubMed ID: 23896291.
    Abstract:
    Curcumin (Cur) has putative antitumor properties. In the current study, we examined photophysical and photochemical properties of Cur using laser flash photolysis. The results demonstrated that Cur could be photo-ionized at 355 nm laser pulse to produce radical cation (Cur(+)) and solvated electron e(sol)(-) in 7:3 ethanol-water mixtures. The quantum yield of Cur photo-ionization and the ratio of photo-ionization to photo-excitation were also determined. Cur(+) could be transferred into neutral radical of Cur (Cur) via deprotonation with the pKa 4.13. The excited singlet of Cur ((1)Cur* could be transferred into excited triplet ((3)Cur*, which could be quenched by oxygen to produce singlet oxygen (1)O2*. Reaction of (3)Cur* with tryptophan was confirmed. The results encourage developing curcumin as a photosensitive antitumor agent.
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