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  • Title: No acute suppression of cerebrospinal fluid corticotropin-releasing hormone in man by cortisol administration.
    Author: Kellner M, Salzwedel C, Wortmann V, Urbanowicz T, Boelmans K, Yassouridis A, Stalla GK, Wiedemann K.
    Journal: Psychiatry Res; 2013 Dec 15; 210(2):662-4. PubMed ID: 23896353.
    Abstract:
    Corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) is regarded as index of brain endocrine and behavioral functioning. We investigated the acute effects of intravenous cortisol (100mg) vs. placebo on serial CSF CRH in ten healthy men. CSF CRH concentrations were not significantly suppressed by cortisol within 3h. The origin and regulation of CSF CRH need further research.
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