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  • Title: From micrograms to grams: scale-up synthesis of eribulin mesylate.
    Author: Yu MJ, Zheng W, Seletsky BM.
    Journal: Nat Prod Rep; 2013 Sep; 30(9):1158-64. PubMed ID: 23896896.
    Abstract:
    The synthesis of eribulin mesylate from microgram to multi-gram scale is described in this Highlight. Key coupling reactions include formation of the C30a to C1 carbon-carbon bond and macrocyclic ring closure through an intramolecular Nozaki-Hiyama-Kishi reaction.
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