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  • Title: [Long-term arterial infusion chemotherapy in advanced and recurrent gastric cancer patients at home and an interesting autopsy case].
    Author: Sato M, Terashima M, Takagane A, Saito K.
    Journal: Gan To Kagaku Ryoho; 1990 Aug; 17(8 Pt 2):1793-8. PubMed ID: 2389967.
    Abstract:
    Arterial infusion therapy was applied to 92 patients with 40 unresectable, 30 non-curatively resected and 22 recurrent gastric cancers. 5-Fluorouracil (5-FU) was administered by arterial continuous infusion, Adriamycin (ADM) and mitomycin C (MMC) were given by bolus infusion in the hospital, and continuous arterial 5-FU infusion and ADM low-dose intermittent bolus infusion chemotherapy (AF therapy) were used for outpatients at home. The clinical effectiveness was evaluated. One-year cumulative survival rate of primary case by Kaplan-Meier method was 21.6%, and that of recurrent gastric cancer was 4.5%. In primary cases, the arterial infusion therapy was more effective in non-curatively resected cases than in unresectable ones. Total periods of infusion for outpatients were longer in efficacious cases. A long-surviving autopsy case was reported. AF therapy was considered an effective supportive treatment without any serious side effects for unresectable, non-curatively resected and recurrent gastric cancer, especially responders.
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