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  • Title: Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.
    Author: Thévenin M, Thoret S, Grellier P, Dubois J.
    Journal: Bioorg Med Chem; 2013 Sep 01; 21(17):4885-92. PubMed ID: 23902828.
    Abstract:
    A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Trypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation.
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