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  • Title: Effect of isosorbide dinitrate on enzymatically estimated infarction size and on clinical condition of the patients of acute myocardial infarction.
    Author: Mukherjee D, Lodh SK, Sengupta M, Maity AK, Mondal AK, Ghose JC.
    Journal: Indian J Pathol Microbiol; 1990 Apr; 33(2):144-50. PubMed ID: 2391145.
    Abstract:
    With the aim of reducing myocardial infarction size, isosorbide dinitrate (ISDN) was tried in 27 patients of acute myocardial infarction (AMI). There was 11% reduction of infarction size, in the ISDN treated group, in comparison to that of non treated group, though the result was not statistically significant. But, many of the in-hospital complications were significantly less in the treated group. After a critical analysis of the result it was concluded that a statistically insignificant result, as regard reduction of infarction size in AMI, cannot always exclude the utility of a drug therapy in AMI.
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