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  • Title: The MFS-type efflux pump Flr1 induced by Yap1 promotes canthin-6-one resistance in yeast.
    Author: Dejos C, Régnacq M, Bernard M, Voisin P, Bergès T.
    Journal: FEBS Lett; 2013 Sep 17; 587(18):3045-51. PubMed ID: 23912082.
    Abstract:
    Screening for suppressors of canthin-6-one toxicity in yeast identified Yap1, a transcription factor involved in cell response to a broad range of injuries. Although canthin-6-one did not promote a significant oxidative stress, overexpression of YAP1 gene clearly increased resistance to this drug. We demonstrated that Yap1-mediated resistance involves the plasma membrane major-facilitator-superfamily efflux pump Flr1 but not the vacuolar ATP-binding-cassette transporter Ycf1. FLR1 overexpression was sufficient to reduce sensitivity to the drug, but strictly dependent on a functional YAP1 gene.
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