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  • Title: Prostaglandins and the anti-inflammatory activities of aspirin and sodium salicylate.
    Author: Smith MJ, Ford-Hutchinson AW, Elliott PN.
    Journal: J Pharm Pharmacol; 1975 Jul; 27(7):473-8. PubMed ID: 239150.
    Abstract:
    Acetylsalicylic acid (aspirin) and sodium salicylate are equally effective in reducing the swelling in the carrageenan-induced paw test and the accumulation of leucocytes into the inflammatory exudate produced by the subcutaneous implantation of polyvinyl sponges in the rat. Aspirin but not sodium salicylate caused a significant reduction in the potentiation of paw oedema found after the concurrent administration of carrageenan and arachidonic acid. Some implications of these findings are discussed.
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