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  • Title: [Clinical efficacy and safety of norfloxacin tablets in pediatrics].
    Author: Morita H, Tomoda T, Araki K, Kurashige T, Nishibayashi Y, Matsumoto K, Zushi N.
    Journal: Jpn J Antibiot; 1990 May; 43(5):884-9. PubMed ID: 2391760.
    Abstract:
    We have evaluated norfloxacin (NFLX) tablets for therapeutic effectiveness and safety in children. The results are summarized as follows. 1. A clinical study was performed on 14 children with infections, including 12 with urinary tract infections and 2 with acute bronchitis. Doses ranging from 1.7 to 5.4 mg/kg body weight were given b.i.d. or t.i.d.. Lengths of treatment ranged from 3 to 15 days. The therapeutic responses were considered "excellent" in 8 and "good" in 5, with an efficacy rate of 93%. 2. Side effects were observed in 2 cases, one with light-headed feeling and one with vomiting. In clinical laboratory tests, eosinophilia was found in 2 cases and GOT was slightly elevated in 1 case. It has been concluded that NFLX is a usable drug for the treatment of bacterial infections in children.
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