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  • Title: Metallo-β-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem.
    Author: Hiraiwa Y, Morinaka A, Fukushima T, Kudo T.
    Journal: Bioorg Med Chem; 2013 Sep 15; 21(18):5841-50. PubMed ID: 23920484.
    Abstract:
    3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-β-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-β-lactamase, IMP-1 inhibitory activity and a strong combination effect with biapenem (BIPM), carbapenem antibiotic. In particular, the 4'-hydroxy-piperidine derivative showed strong IMP-1 inhibitory activity and a combination effect with various antibiotics.
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