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  • Title: [The effect of hydrophobization of glucose-6-phosphate dehydrogenase with progesterone on its thermal inactivation].
    Author: Karaseva EI, Eremin AN, Metelitsa DI.
    Journal: Prikl Biokhim Mikrobiol; 1990; 26(3):341-8. PubMed ID: 2392417.
    Abstract:
    Thermal inactivation of glucose-6-phosphate dehydrogenase (G6PDH) and its conjugates with progesterone containing 3, 7 and 35 molecules of the modifier was studied in bidistilled water over a temperature range 35-47 degrees. At different temperatures and initial concentrations of the enzyme and its modified forms, thermal inactivation is described by the equation of the first order up to a significant degree of enzyme deactivation. The effective Kin values are decreased with the increase of the native G6PDH concentration and changed in a complicated manner with the increase of the conjugate concentration depending on the enzyme modification degree, which reflects a great role of the enzyme hydrophobicity in its inactivation. The role of hydrophobicity of the modified G6PDH in changes of its specific activity is discussed.
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