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  • Title: [Combined therapy using ranitidine and sucralfate in duodenal ulcer resistant to cimetidine].
    Author: Uribarrena R, Arín A, Valera JI, Oreja M, Burusco MJ, Pueyo A, Fortún MT.
    Journal: Rev Clin Esp; 1990 Apr; 186(7):328-31. PubMed ID: 2392595.
    Abstract:
    122 patients with duodenal ulcus have been treated with a cimetidine's single night dose of 800 mg over 6 or 12 weeks. After this period of time, 18 patients still had their wounds without complete healing. This group of patients had been afterwards treated with a combination of ranitidine and sulfacrate over a six weeks period. Only 3 of them achieved a complete ulcus reepitelization, although all of them were clinically asymptomatic. These 3 patients moved to a nightly maintenance treatment guideline of 150 mg of ranitidine, but they quickly presented relapses. A significantly higher consumption of tobacco and alcohol was observed among the patients who did not heal after 12 weeks of treatment with cimetidine. On the other hand the rest of the general facts and ulcus endoscopic characteristics have been similar both in patients resistant to cimetidine and in those who had a favorable evolution.
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