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  • Title: The pharmacology of recombinant hirudin, a new anticoagulant.
    Author: Meyer BH, Luus HG, Müller FO, Badenhorst PN, Röthig HJ.
    Journal: S Afr Med J; 1990 Sep 01; 78(5):268-70. PubMed ID: 2392724.
    Abstract:
    A new anticoagulant, recombinant hirudin, was given to healthy volunteers (5 per test dose) in single intravenous doses of 0.01, 0.02, 0.04, 0.07 and 0.1 mg/kg to study its anticoagulant effects, how it was tolerated and its pharmacokinetics. Hirudin proved to be a potent anticoagulant with important effects on thrombin (increase in thrombin time and partial thromboplastin time). The maximum pharmacodynamic effect was achieved with the 0.07 mg/kg dose, and upwards. All doses of the compound were tolerated without side-effects. The mean elimination half-life is about 1 hour. Mean total clearance and volume of distribution are approximately 190 ml/min and 14 l, respectively. Hirudin obeys first-order pharmacokinetics.
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