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  • Title: Thermodynamics-based mathematical model for solubility prediction of glibenclamide in ethanol-water mixtures.
    Author: Shakeel F, Alanazi FK, Alsarra IA, Haq N.
    Journal: Pharm Dev Technol; 2014 Sep; 19(6):702-7. PubMed ID: 23930969.
    Abstract:
    Temperature-dependent solubility data of glibenclamide (GBN) in various ethanol-water mixtures is not reported in literature so far. Therefore, the aim of this study was to determine the mole fraction solubility of GBN in various ethanol-water mixtures at the temperature range of 293.15 to 318.15 K. The solubility of GBN was determined by reported shake flask method and the experimental data was fitted in thermodynamics-based modified Apelblat model. The solubility of GBN was found to be increased with increase in temperature and mass fraction of ethanol in ethanol-water mixtures. The experimental data of GBN was well correlated with the modified Apelblat model at each temperature range with correlation coefficient of 0.9940-1.0000. The relative absolute deviation (AD) was found to be less than 0.1% except in pure ethanol and water. The positive values of enthalpies and entropies for GBN dissolution indicated that its dissolution is endothermic and an entropy-driven process.
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