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  • Title: Tip-enhanced Raman spectroscopy for the base interrogation of DNA.
    Author: Kolodziejski N.
    Journal: Methods Cell Biol; 2013; 114():611-28. PubMed ID: 23931525.
    Abstract:
    A combination of scanning probe and Raman microscopies allows for the label-free chemical mapping of surfaces with spatial resolutions one to two orders of magnitude below the diffraction limit. Because Raman spectroscopy provides a highly specific molecular "fingerprint," the resulting spectra allow speciation of even highly similar chemical compounds. The surface enhancement phenomenon allows Raman signals from a species to be enhanced by many orders of magnitude within the vicinity (~10nm) of a source of free electrons such as a noble metal. Presenting the metal surface as a single highly localized point, and moving this point with angstrom accuracy across a distributed, heterogenous surface while collecting Raman spectra, is what is known as tip-enhanced Raman spectroscopy, or TERS.
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