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  • Title: [Effect of calcium antagonists on the Ca2(+) paradox].
    Author: Tribulová N, Slezák J, Ravingerová T, Okruhlicová L.
    Journal: Bratisl Lek Listy; 1990 Jun; 91(6):437-45. PubMed ID: 2393826.
    Abstract:
    The model of calcium paradox was used to test the effect of the calcium entry blocker Diltiazem (concentration 4.0 mumol.l-1) and of the calmodulin inhibitor Trifluoroperazin (concentration 1.0 mumol.l-1). Application of each preparation resulted in improved cardiac function manifested by restoration of the electrical and contractile activity and by increased coronary flow. Both Diltiazem and Trifluoroperazin exerted a protective effect on the preservation of enzymatic activities and of ultrastructure in conditions of impaired calcium homeostasis.
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