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  • Title: Squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to nitroalkenes.
    Author: Li JH, Du DM.
    Journal: Org Biomol Chem; 2013 Sep 28; 11(36):6215-23. PubMed ID: 23939139.
    Abstract:
    An efficient chiral squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to nitroalkenes has been developed. This reaction afforded the chiral pyrazol-3-ol derivatives in high to excellent yields (up to >99%) with high enantioselectivities (up to 94% ee) for most substrates under very low catalyst loading (0.25 mol%). This catalytic asymmetric reaction provides valuable and easy access to chiral pyrazol-3-ol derivatives, which possess potential pharmaceutical activity.
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