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  • Title: Use of sulfated cyclofructan 6 and sulfated cyclodextrins for the chiral separation of four basic pharmaceuticals by capillary electrophoresis.
    Author: Zhang YJ, Huang MX, Zhang YP, Armstrong DW, Breitbach ZS, Ryoo JJ.
    Journal: Chirality; 2013 Nov; 25(11):735-42. PubMed ID: 23939835.
    Abstract:
    Sulfated cyclofructan 6 (S-CF6) and sulfated cyclodextrins (S-α-, β-, γ-CDs) are highly selective chiral selectors for the enantioseparation of basic solutes. In this study, S-CF6 was introduced for the enantiomeric separation of four basic pharmaceuticals (including tamsulosin, tiropramide, bupivacaine, and norephedrine) by capillary electrophoresis (CE), and the enantiomeric separation performance was compared with S-α-, β-, γ-CDs. The effects of the chiral selector type, chiral selector concentration, operating voltage, and column temperature were examined and optimized. Excellent resolutions were obtained for all solutes on these chiral selectors.
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