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  • Title: Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.
    Author: Banerjee S, Kitchen JA, Bright SA, O'Brien JE, Williams DC, Kelly JM, Gunnlaugsson T.
    Journal: Chem Commun (Camb); 2013 Oct 04; 49(76):8522-4. PubMed ID: 23942760.
    Abstract:
    The bi-functional complex [Pt(II)(terpy)(py-naphth)](NO3)2(), incorporating both 2,2':6',2''-terpyridine and 4-N,N'-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.
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