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  • Title: Effects of polymorphic DNA on the fluorescent properties of silver nanoclusters.
    Author: Li W, Liu L, Fu Y, Sun Y, Zhang J, Zhang R.
    Journal: Photochem Photobiol Sci; 2013 Oct; 12(10):1864-72. PubMed ID: 23946050.
    Abstract:
    Silver nanoclusters (Ag NCs) with emission wavelengths from 538 nm to 706 nm were synthesized using a series of G-/C-rich polymorphic DNA templates. Thermodynamic studies on the interactions of Ag(+) with polymorphic DNA indicate that the binding affinities greatly depend on the secondary structures of DNA templates, with a decreasing order: the coiled C-rich strand > the i-motif > the duplex > the G-quadruplex. Fluorescent Ag NCs prepared using these polymorphic DNA templates show that fluorescence stabilities are associated with the binding affinities between DNA templates and Ag(+), e.g., the coiled C-rich strand C4A4C3 with the highest binding constant (40.2 × 10(5) M(-1)) stabilizes Ag NCs for over 300 h, while the G-quadruplex G4T4G4 with the lowest binding constant (0.64 × 10(5) M(-1)) generates Ag NCs with the shortest shelf-life (55 h). The cluster sizes of Ag NCs are associated with the sequence lengths of DNA templates. In addition, the red emitting [C4A4C3]-Ag and the NIR emitting [G4T4G4-C4A4C4]-Ag are successfully used for HeLa cell transfection and exhibit good intracellular emission. These results provide a promising pathway to prepare silver nanomaterials with desirable physicochemical properties through designing suitable DNA templates.
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