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  • Title: [Changes and clinical significance of serum level of syndecan-4 protein in patients with chronic congestive heart failure].
    Author: Ma X, Ouyang P, Zhang Z, Lai W, Xu D.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2013 Aug; 29(8):866-9. PubMed ID: 23948417.
    Abstract:
    OBJECTIVE: To detect serum level of syndecan-4 protein in patients with chronic congestive heart failure (CHF) and investigate its correlation with New York Heart Association (NYHA) class and echocardiographic parameters. METHODS: The concentration of serum syndecan-4 protein was measured by enzyme-linked immunosorbent assay (ELISA) in 40 patients with CHF and 40 healthy controls (NCD), respectively. The parameters such as left ventricle ejection fraction (LVEF), fraction shortening (FS), left ventricle end-diastolic diameter (LVDd), left ventricle end-systolic diameter (LVDs), left ventricle end-diastolic volume (LVEDV) and left ventricle end-systolic volume (LVESV) were detected by echocardiography in 40 patients of CHF. Meanwhile, the patients' cardiac function was graded according to NYHA class. RESULTS: The levels of serum syndecan-4 protein significantly increased in CHF group as compared with control group (P<0.01). In CHF group, as the increased grading of NYHA cardiac function, the levels of serum syndecan-4 protein significantly increased (P<0.05). The more upgraded the NYHA grading, the higher level of serum syndecan-4 protein. In bivariate correlations analysis showed that the level of serum syndecan-4 protein was significantly negatively correlated with LVEF and FS (P<0.05) and was significantly positively correlated with LVDd, LVDs, LVEDV and LVESV, respectively (P<0.05). CONCLUSION: Serum syndecan-4 concentration significantly increased in CHF patients, and it was closely correlated with NYHA class and left ventricle function parameters, so the level of serum syndecan-4 protein may have an important value in detection and surveillance of CHF.
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