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  • Title: Oxalate nephropathy in a Tibetan spaniel litter. A probable case of primary hyperoxaluria.
    Author: Jansen JH, Arnesen K.
    Journal: J Comp Pathol; 1990 Jul; 103(1):79-84. PubMed ID: 2394849.
    Abstract:
    Severe oxalate nephropathy with end-stage kidney lesions was found in two pups of a litter of three Tibetan Spaniels. This histopathological finding strongly suggests a primary hyperoxaluria since there was no exposure to agents capable of producing secondary hyperoxaluria. Primary hyperoxaluria has not been reported as a spontaneous disease in the dog, although it is a well-known, but rare, inherited metabolic disease of man.
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