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  • Title: Lectin-binding sites in clear cell acanthoma.
    Author: Akiyama M, Hayakawa K, Watanabe Y, Nishikawa T.
    Journal: J Cutan Pathol; 1990 Aug; 17(4):197-201. PubMed ID: 2394862.
    Abstract:
    Lectin-binding sites in clear cell acanthoma (CCA) were studied using an avidin-biotin complex (ABC) with 9 lectins. Formaldehyde-fixed, paraffin-embedded sections of 7 CCA lesions were employed. Positive stainings, similar to those seen in normal epidermis, were observed on the cell surface in CCA with Ricinus communis agglutinin I (RCA-I), Ricinus communis agglutinin II (RCA-II), and wheat germ agglutinin (WGA). Reduced reactivities were observed with Concanavalin A (ConA) and peanut agglutinin (PNA) in CCA. In some areas of CCA lesions, faint stainings were seen with Ulex europaeus agglutinin I (UEA-I). Capability of staining with soybean agglutinin (SBA) was completely lost in the lesions. With Bandeiraea simplicifolia agglutinin II (BSA-II), cytoplasmic stain was seen in a part of upper and spinous layers in CCA lesions. Dolichos biflorus agglutinin (DBA) did not bind to either CCA or normal epidermis. These results indicate that the lectin-binding sites of proliferating cells of CCA resemble those of epidermal keratinocytes and suggest that CCA is a tumor of epidermal origin.
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