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  • Title: Effect of DL-ethionine on blood clearance of 99mTc-phytate in dogs.
    Author: Shibata H, Kohno M.
    Journal: J Toxicol Sci; 1990 May; 15(2):97-106. PubMed ID: 2395183.
    Abstract:
    The effect of DL-ethionine (EthN) on the blood clearance of 99mTc-phytate (99mTc-P) in dogs was examined, and the blood clearance test of 99mTc-P was compared with the cases of the serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in dogs increased dose-dependently after the administration of EthN. The disappearance rate of 99mTc-P from blood in dogs decreased with the increase in dose of EthN and with the passage of time after EthN administration. Changes of the blood clearance of 99mTc-P after EthN treatment in dogs may be influenced by the disorder in the hepatocytes. The blood clearance test of 99mTc-P in dogs showed a reaction for the acute hepatic dysfunction induced by EthN equally to the serum transaminase and bilirubin test.
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