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  • Title: The effects of copper, zinc, mercury, and cadmium on rabbit erythrocytic porphobilinogen synthase in vivo.
    Author: Farant JP, Wigfield DC.
    Journal: J Anal Toxicol; 1990; 14(4):222-6. PubMed ID: 2395343.
    Abstract:
    The interactions of Zn2+, Hg2+, Cd2+, and Cu2+ with normal and lead-intoxicated rabbit erythrocytic porphobilinogen synthase (PBG-S) were studied in vivo. The results obtained show that each divalent ion has a characteristic effect on the pH-activity relationship of PBG-S. The effects for a given ion were both pH and concentration dependent and were similar to those obtained in vitro. Lead was found to be the most potent effector in vivo.
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