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  • Title: Stimulation of mitochondrial pyruvate transport in rat renal cortex by phenylephrine.
    Author: Oliver J, Sola MM, Salto R, Vargas AM.
    Journal: Life Sci; 1990; 47(5):401-6. PubMed ID: 2395410.
    Abstract:
    Phenylephrine effect on liver and kidney cortex mitochondrial pyruvate concentration was investigated. While in liver the alpha 1-adrenergic agent produced a decrease in pyruvate content, a significant increase was observed in kidney, even in the presence of 0.5 mM alpha-cyano-4-hydroxy-cinnamate. These changes were not observed when pyruvate was formed by intramitochondrial transamination of alanine, suggesting a role for the pyruvate transport across mitochondrial membranes in the regulation of mitochondrial pyruvate metabolism in kidney cortex. This was corroborated measuring the phenylephrine effect on pyruvate carboxylation.
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