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  • Title: A case of IgD myeloma representing a missed biclonal paraproteinemia or isotype switch in a patient previously diagnosed with IgA-lambda myeloma.
    Author: Chepovetsky J, Chari A, Jagannath S, Ramanthan L.
    Journal: Clin Chim Acta; 2013 Oct 21; 425():233-5. PubMed ID: 23954772.
    Abstract:
    BACKGROUND: Multiple myeloma is a clonal plasma cell neoplasm that is identified in the laboratory by a presence of a monoclonal immunoglobulin or increased plasma light chain levels. METHODS: The most commonly identified and tested immunoglobulins are IgA, IgG and IgM. RESULTS: Rare cases of multiple myeloma present with monoclonal IgD and IgE paraproteins. CONCLUSION: We present a case of IgD myeloma diagnosed in a patient who had achieved partial remission from a previously diagnosed IgA myeloma, possibly representing a missed biclonal paraproteinemia or isotype switch after treatment.
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