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  • Title: Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens.
    Author: Liu X, Yang XW, Chen CQ, Wu CY, Zhang JJ, Ma JZ, Wang H, Yang LX, Xu G.
    Journal: J Nat Prod; 2013 Sep 27; 76(9):1612-8. PubMed ID: 23957453.
    Abstract:
    Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC₅₀ 5.8-17.9 μM) against the tested tumor cell lines.
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