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Title: Differential gene expression in peripheral blood T cells from patients with psoriasis, lichen planus, and atopic dermatitis. Author: Li X, Li J, Yang Y, Hou R, Liu R, Zhao X, Yan X, Yin G, An P, Wang Y, Zhang K. Journal: J Am Acad Dermatol; 2013 Nov; 69(5):e235-e243. PubMed ID: 23958114. Abstract: BACKGROUND: Psoriasis, lichen planus (LP), and atopic dermatitis (AD) are common chronic inflammatory skin diseases mediated by immune responses. OBJECTIVE: We used RNA sequencing to investigate messenger RNA expression patterns in peripheral T cells of Chinese patients with psoriasis, LP, or AD and of healthy individuals. METHODS: After peripheral T-cell proliferation, messenger RNA expression patterns were investigated by RNA sequencing, and 6 randomly selected genes were verified by real-time reverse transcriptase polymerase chain reaction. RESULTS: Six genes were down-regulated and 33 were up-regulated in these diseases. Gene ontology analysis revealed enrichment of genes involved in positive regulation of T-cell activation. Regulation of nuclear premessenger RNA domain containing 1B (RPRD1B) expression was enhanced in psoriasis. LIMITATIONS: The role of hereditary factors in RPRD1B expression in T cells was not considered. Immunomodulators (thymopeptide, levamisole, BCG polysaccharide, nucleic acid injection, and transfer factor) were previously given to patients with psoriasis and LP, but not to patients with AD; the effects of these immunomodulators on gene expression is uncertain. CONCLUSION: RPRD1B may be involved in T-cell activation in our Chinese psoriatic cohort, and may play a role in stimulating epidermal hyperproliferation.[Abstract] [Full Text] [Related] [New Search]