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  • Title: [Immunogenetic analysis of delayed hypersensitivity to tuberculin in mice by the method of local adoptive transfer].
    Author: Mezhlumova MB.
    Journal: Probl Tuberk; 1990; (4):55-8. PubMed ID: 2395849.
    Abstract:
    It has been demonstrated that a specific phase of DTH reaction to tuberculin is carried out (and in adoptive transfer-transferred) by T-lymphocytes with Lyt-1+, Lyt-2-, L3T4+ phenotype by a method of local adoptive transfer of this reaction from BCG-immunized mice to the pads of intact recipients. From genetic viewpoint, the above reaction is limited by 1-A beta, 1-A alpha genes. In a syngeneic apposition, monoclonal antibodies anti-1-A kappa beta (without complement) were blocking the reaction transfer to CBA mice A beta chain affected mutation bm12 failed to limit the reaction transfer in apposition B6----B6.C-H-2bm12.
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