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  • Title: [Erythroid colonies derived from BFU-E from the bone marrow in a patient with type I congenital dyserythropoietic anemia].
    Author: Florensa L, Woessner S, Almarcha J, Pardo Peret P, Lafuente R, Vilá RM.
    Journal: Sangre (Barc); 1990 Jun; 35(3):219-21. PubMed ID: 2396168.
    Abstract:
    The findings of in vitro culture of bone-marrow BFU-E from a patient with type I dyserythropoietic anaemia are reported, scarce data being seemingly available in the literature. The number of BFU-E in the culture was increased four-fold with respect to the normal values. The morphologic study of the colonies showed in all cases varying number of erythroblasts with internuclear bridges (5-20%). Upon ultrastructural examination of the colonies, a great number of erythroblasts exhibited morphologic alterations, spongy chromatin and internuclear bridges being commonest. These findings suggest that an alteration of the progenitor erythroid cells exists in type I dyserythropoietic anaemia, whereas the morphological defects appreciated show great variation in the progeny of each BFU-E.
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