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  • Title: Analysis of serum placental alkaline phosphatase activity in testicular cancer and cigarette smokers.
    Author: Koshida K, Stigbrand T, Munck-Wikland E, Hisazumi H, Wahren B.
    Journal: Urol Res; 1990; 18(3):169-73. PubMed ID: 2396349.
    Abstract:
    Serum PLAP/PLAP-like enzymes are elevated in testicular cancer patients and also in heavy smokers. Such elevations were measurable with anti-PLAP polyclonal and monoclonal antibodies, and an antigenic heterogeneity was demonstrated in the circulating enzymes. Thus polyclonal antibody revealed more of tumor PLAP-like antigen while a monoclonal antibody H7 detected PLAP of smokers better. PLAP of smokers and PLAP-like enzyme of cancer (seminoma) patients showed similar characteristics with respect to glycosylation pattern, charge and hydrophobicity. By these properties they were differentiated from PLAP of placenta.
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