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  • Title: Ultrasensitive detection of small molecule-protein interaction via terminal protection of small molecule linked DNA and Exo III-aided DNA recycling amplification.
    Author: Zhou G, Zhang X, Ji X, He Z.
    Journal: Chem Commun (Camb); 2013 Oct 09; 49(78):8854-6. PubMed ID: 23964359.
    Abstract:
    Terminal protection of small molecule linked DNA assays amplified by Exo III-aided DNA recycling is developed for the detection of streptavidin-biotin interaction, with a detection limit of 0.8 fM streptavidin in the "turn-on" state, indicating that the proposed method is an ultrasensitive platform for the detection of small molecule-protein interactions.
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