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  • Title: R292K substitution and drug susceptibility of influenza A(H7N9) viruses.
    Author: Sleeman K, Guo Z, Barnes J, Shaw M, Stevens J, Gubareva LV.
    Journal: Emerg Infect Dis; 2013; 19(9):1521-4. PubMed ID: 23965618.
    Abstract:
    Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
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