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  • Title: A new turn-on fluorescent chemosensor based on diketopyrrolopyrrole (DPP) for imaging Zn2+ in living cells.
    Author: Zhang G, Li H, Bi S, Song L, Lu Y, Zhang L, Yu J, Wang L.
    Journal: Analyst; 2013 Oct 21; 138(20):6163-70. PubMed ID: 23971073.
    Abstract:
    A new turn-on fluorescent chemosensor, DPPL1, was rationally designed and synthesized based on diketopyrrolopyrrole (DPP), which presented high sensitivity and selectivity for Zn(2+). Specifically, DPPL1 presented a large emission enhancement and a 70 nm blue-shift upon Zn(2+) binding. (1)H NMR titrations, studies into the pH effects and DFT calculations further proved that this phenomenon was due to both photo-induced electron transfer (PET) and intra-molecular charge transfer (ICT) processes. More importantly, DPPL1 was successfully used for imaging Zn(2+) in living HeLa cells. To the best of our knowledge, this is the first DPP-based fluorescent chemosensor to recognize Zn(2+) ions in living cells with a large blue-shift and a fluorescent enhancement based on both photo-induced electron-transfer (PET) and intramolecular charge-transfer (ICT) effects. Meanwhile, we have also provided a new effective platform for the development of fluorescent chemosensors for other analytes.
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