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  • Title: [Effects of burn injury on the reactivity of spleen cells of mice of different genotypes during regional graft vs host reaction].
    Author: Barsukov AN, Fedorov GN, Semenkov VF.
    Journal: Biull Eksp Biol Med; 1990 Jun; 109(6):592-4. PubMed ID: 2397303.
    Abstract:
    Different strains of mice CBA (H-2k) and C57BL/6 (H-2b) have been exposed to burn of flame of 15% skin-deep of body. Spleen cells were received 6 hours, 3 and 7 days after burn trauma of mice in order to induce the local graft-versus-host reaction by subcutaneous injection of 10(7) cells in foot of hind leg of (CBA X C57BL/6)F1 hybrids. The enhancement of the ability of spleen cells to induce graft-versus host was observed in 6 hours and 3 days. The burn trauma of C57BL/6 mice produced the suppression of reactivity of spleen cells in graft-versus-host reaction for all terms of research. The donors of spleen cells adrenalectomy 5 days before the burn trauma eliminated differences of reactivity of lymphocytes of mice CBA and C57BL/6.
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